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The Japan Food Chemical Research Foundation
List of Designated Additives-flavorings4
Last update:08/13/2013

Lactones (except those generally recognized as highly toxic)
The examples of flavorings used for food in Japan: The result of investigation by Japan Flavor & Fragrance Material Association in 2013.
Compound
CAS No.
ambrettolide123-69-3
7779-50-2
alpha-angelicalactone591-12-8
3-butylidenephthalide551-08-6
gamma-butyrolactone96-48-0
15-pentadecanolide106-02-5
delta-decalactone705-86-2
gamma-decalactone706-14-9
7-decen-4-olide67114-38-9
9-decen-5-olide74585-00-5
2-decen-5-olide54814-64-1
7-decen-5-olide25524-95-2
34686-71-0
dihydroactinidiolide15356-74-8
17092-92-1
19432-05-4
81800-41-1
16-hexadecanolide109-29-5
dihydrocoumarin119-84-6
2-hydroxy-3,3-dimethyl-4-butanolide79-50-5
2,3-dimethyl-2-nonen-4-olide10547-84-9
delta-dodecalactone713-95-1
gamma-dodecalactone2305-05-7
6-dodecen-4-olide18679-18-0
epsilon-decalactone5579-78-2
epsilon-dodecalactone16429-21-3
2-hydroxy-3-methyl-2-hexen-4-olide698-10-2
1,4-dioxacycloheptadecane-5,17-dione105-95-3
delta-heptalactone3301-90-4
gamma-heptalactone105-21-5
2-heptyl-4-pentanolide40923-64-6
gamma-hexadecalactone730-46-1
delta-hexadecalactone7370-44-7
delta-hexalactone823-22-3
gamma-hexalactone695-06-7
4-methyl-cis-7-decen-4-olide70851-61-5
2-hydroxy-3-methyl-2-penten-4-olide28664-35-9
8-undecen-5-olide68959-28-4
8-decen-5-olide32764-98-0
(R)-2-decen-5-olide51154-96-2
menthone lactone499-54-7
4-methyl-4-decanolide7011-83-8
2-methyl-4-butanolide1679-47-6
3-methyl-4-octanolide39212-23-2
3,6-dimethyl-5,6,7,7a-tetrahydro-2(4H)-benzofuranone13341-72-5
38049-04-6
delta-nonalactone3301-94-8
2-nonen-4-olide21963-26-8
delta-octadecalactone1227-51-6
octahydro-2H-1-benzopyran-2-one4430-31-3
delta-octalactone698-76-0
gamma-octalactone104-50-7
2,4-decadien-5-olide27593-23-3
3-propylidenephthalide17369-59-4
sclareolide564-20-5
delta-tetradecalactone2721-22-4
delta-tridecalactone7370-92-5
delta-undecalactone710-04-3
delta-valerolactone542-28-9
gamma-valerolactone108-29-2
4-methyl-5-hexen-4-olide1073-11-6
2,3-dimethyl-2,4-nonadien-4-olide774-64-1
2-buten-4-olide497-23-4
3-decen-4-olide81715-81-3
3-methyl-trans-5-decen-4-olide 
3-nonen-4-olide51352-68-2
4-butyl-4-octanolide7774-47-2
3-ethyl-2-oxo-4-butanolide923291-29-6
beta-angelicalactone591-11-7
3-methyl-4-nonanolide33673-62-0
cis-7-decen-4-olide63095-33-0
(-)-2-hydroxy-3,3-dimethyl-4-butanolide599-04-2
3,6-dimethylhexahydro-2(3H)-benzofuranone92015-65-1
2-oxothiolane1003-10-7
isoambrettolide28645-51-4
3,6-dimethyl-3a,4,5,7a-tetrahydro-2(3H)-benzofuranone57743-63-2
182699-77-0
3-hydroxy-2-pyranone496-64-0
9-dodecen-12-olide301310-73-6
9-dodecen-5-olide15456-68-5
18679-14-6
9-tetradecen-5-olide15456-70-9
4,8-dimethyl-7-nonen-4-olide134359-15-2
3-butylphthalide6066-49-5
3,9-dimethyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decan-2-one831213-72-0
3-methyl-4-decanolide67663-01-8
[To List of designated additives]

Phenol Ethers (except those generally recognized as highly toxic)
The examples of flavorings used for food in Japan: The result of investigation by Japan Flavor & Fragrance Material Association in 2013.
Compound
CAS No.
trans-anethole4180-23-8
anisic acid100-09-4
anisole100-66-3
anisyl ethyl ether55249-73-5
benzyl eugenyl ether57371-42-3
1,2-diethoxybenzene2050-46-6
ethyl 4-methylphenyl ether622-60-6
1,3-dimethoxybenzene151-10-0
1,4-dimethoxybenzene150-78-7
4-ethenyl-1,2-dimethoxybenzene6380-23-0
1,2-dimethoxy-4-methylbenzene494-99-5
2,3-dimethylbenzofuran3782-00-1
diphenyl ether101-84-8
estragole140-67-0
1-ethoxy-2-methoxybenzene17600-72-5
ethyl 2-methoxybenzyl ether64988-06-3
ethyl isoeugenyl ether7784-67-0
isobutyl 2-naphthyl ether2173-57-1
amyl isoeugenyl ether10484-36-3
benzyl isoeugenyl ether120-11-6
1-methoxy-3-methylbenzene100-84-5
methyl 2-naphthyl ether93-04-9
methylphenyl phenyl ether1706-12-3
3586-14-9
3991-61-5
isoeugenyl methyl ether93-16-3
1-methoxy-2-methylbenzene578-58-5
1-methoxy-4-methylbenzene104-93-8
eugenyl methyl ether93-15-2
butyl 2-naphthyl ether10484-56-7
ethyl 2-naphthyl ether93-18-5
1-methoxy-4-propylbenzene104-45-0
methyl thymol ether1076-56-8
1,2,3-trimethoxybenzene634-36-6
1,2-dimethoxybenzene91-16-7
3,4-dimethoxybenzoic acid93-07-2
1-ethenyl-4-methoxybenzene637-69-4
4-tert-butyl-1-methoxy-3-methylbenzene31268-79-8
4-isopropyl-2-methoxy-1-methylbenzene6379-73-3
ethyl phenyl ether103-73-1
1-methoxy-2,4-dimethylbenzene6738-23-4
piperine94-62-2
N-[(2,4-dimethoxyphenyl)methyl]-N'-[2-(2-pyridinyl)ethyl]ethanediamide745047-53-4
3-[(4-amino-2,2-dioxido-1H-2,1,3-benzothiadiazin-5-yl)oxy]-2,2-dimethyl-N-propylpropanamide1093200-92-0
(1R,2S,5R)-N-(4-methoxyphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide68489-09-8

[To List of designated additives]

Phenols (except those generally recognized as highly toxic)
The examples of flavorings used for food in Japan: The result of investigation by Japan Flavor & Fragrance Material Association in 2013.
Compound
CAS No.
4-allyl-2,6-dimethoxyphenol6627-88-9
4-allylphenol501-92-8
carvacrol499-75-2
2-hydroxyphenol120-80-9
creosol93-51-6
3-methylphenol108-39-4
2-methylphenol95-48-7
4-methylphenol106-44-5
2-methoxy-4-propylphenol2785-87-7
2,6-dimethoxyphenol91-10-1
2,3-dimethylphenol526-75-0
2,6-dimethylphenol576-26-1
3,5-dimethylphenol108-68-9
4-ethoxyphenol622-62-8
ethyl eugenyl ether1755-54-0
4-ethyl-2-methoxyphenol2785-89-9
2-ethylphenol90-00-6
3-ethylphenol620-17-7
4-ethylphenol123-07-9
ethylvanillin propyleneglycol acetal68527-76-4
guaiacol90-05-1
4-hydroxybenzoic acid99-96-7
4-hydroxybenzyl alcohol623-05-2
4-(ethoxymethyl)phenol57726-26-8
4-(methoxymethyl)phenol5355-17-9
4-hydroxyphenethyl alcohol501-94-0
2-isopropylphenol88-69-7
4-isopropylphenol99-89-8
3-methoxy-5-methylphenol3209-13-0
3-methoxyphenol150-19-6
4-methoxyphenol150-76-5
4-(1-hydroxyethyl)phenol2380-91-8
2,6-dimethoxy-4-methylphenol6638-05-7
3,4-methylenedioxyphenol533-31-3
2-methoxy-5-methylphenol1195-09-1
4-(methylthio)phenol1073-72-9
phenol108-95-2
4-propylphenol645-56-7
3,4-dihydroxybenzoic acid99-50-3
3-hydroxyphenol108-46-3
salicylic acid69-72-7
4-hydroxy-3,5-dimethoxybenzoic acid530-57-4
thymol89-83-8
2-(methylthio)phenol1073-29-6
vanillic acid121-34-6
vanillin propyleneglycol acetal68527-74-2
4-hydroxy-3-methoxybenzyl alcohol498-00-0
4-(butoxymethyl)-2-methoxyphenol82654-98-6
4-(ethoxymethyl)-2-methoxyphenol13184-86-6
2-ethoxy-5-(1-propenyl)phenol94-86-0
4-ethenyl-2-methoxyphenol7786-61-0
4-ethenylphenol2628-17-3
2,4-dimethylphenol105-67-9
2,5-dimethylphenol95-87-4
3,4-dimethylphenol95-65-8
4-tert-butylphenol98-54-4
2,3,6-trimethylphenol2416-94-6
2-propylphenol644-35-9
3-tert-butylphenol585-34-2
N-(4-hydroxy-3-methoxybenzyl)nonanamide2444-46-4
vanillin 2,3-butanediol acetal63253-24-7
2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-chromen-7-ol76426-35-2
[To List of designated additives]

Terpene Hydrocarbons
The examples of flavorings used for food in Japan: The result of investigation by Japan Flavor & Fragrance Material Association in 2013.
Compound
CAS No.
allo-ocimene673-84-7
alpha-bisabolene17627-44-0
bisabolene495-62-5
beta-bourbonene5208-59-3
delta-cadinene483-76-1
camphene79-92-5
5794-03-6
3-carene13466-78-9
alpha-humulene6753-98-6
beta-caryophyllene87-44-5
alpha-cedrene469-61-4
p-cymene99-87-6
1-isopropenyl-4-methylbenzene1195-32-0
cis-3,7-dimethyl-1,3,6-octatriene3338-55-4
delta-elemene20307-84-0
beta-elemene515-13-9
33880-83-0
alpha-farnesene502-61-4
28973-99-1
125037-13-0
beta-farnesene18794-84-8
77129-48-7
farnesene 
germacrene D23986-74-5
beta-guaiene88-84-6
d-limonene5989-27-5
l-limonene5989-54-8
limonene138-86-3
longifolene475-20-7
19067-29-9
myrcene123-35-3
beta-ocimene13877-91-3
alpha-phellandrene99-83-2
alpha-pinene80-56-8
beta-pinene127-91-3
sabinene3387-41-5
alpha-terpinene99-86-5
gamma-terpinene99-85-4
terpinolene586-62-9
thujopsene470-40-6
valencene4630-07-3
alpha-copaene3856-25-5
isocaryophyllene118-65-0
pinene dimer6993-66-4
[To List of designated additives]

Thioethers (except those generally recognized as highly toxic)
The examples of flavorings used for food in Japan: The result of investigation by Japan Flavor & Fragrance Material Association in 2013.
Compound
CAS No.
acetaldehyde difurfuryl thioacetal 
allyl methyl disulfide2179-58-0
allyl methyl sulfide10152-76-8
allyl methyl trisulfide34135-85-8
allyl propyl disulfide2179-59-1
allyl propyl sulfide27817-67-0
allyl propyl trisulfide33922-73-5
benzothiazole95-16-9
benzyl methyl disulfide699-10-5
benzyl methyl sulfide766-92-7
bis(2-methyl-3-furyl) disulfide28588-75-2
3,5-bis(2-methyltetrahydrofuryl-3)spiro-1,2,4-trithiolane 
butyl propyl disulfide72437-64-0
2-butyl-4,5-dimethylthiazole76572-48-0
2-sec-butylthiazole18277-27-5
2-butylthiophene1455-20-5
butanal dibenzyl thioacetal101780-73-8
diallyl disulfide2179-57-9
diallyl polysulfides72869-75-1
diallyl sulfide592-88-1
dibenzyl disulfide150-60-7
dibutyl sulfide544-40-1
dicyclohexyl disulfide2550-40-5
diethyl disulfide110-81-6
diethyl sulfide352-93-2
difurfuryl disulfide4437-20-1
difurfuryl sulfide13678-67-6
diisoamyl disulfide2051-04-9
diisopropyl disulfide4253-89-8
diisopropyl sulfide625-80-9
dimethyl sulfide75-18-3
dimethyl tetrasulfide5756-24-1
dimethyl trisulfide3658-80-8
3,5-dimethyl-1,2,4-trithiolane23654-92-4
2,5-epoxy-2,5-dimethyl-1,4-dithiane 
2-ethyl-4,5-dimethylthiazole873-64-3
2-isobutyl-4,5-dimethyl-3-thiazoline65894-83-9
4,5-dimethyl-2-propylthiazole41981-72-0
2,4-dimethylthiazole541-58-2
2,5-dimethylthiazole4175-66-0
4,5-dimethylthiazole3581-91-7
2,5-dimethylthiophene638-02-8
3,4-dimethylthiophene632-15-5
dinonyl sulfide929-98-6
bis(2-methylphenyl) disulfide4032-80-8
dipropyl polysulfides72869-76-2
dipropyl sulfide111-47-7
dipropyl trisulfide6028-61-1
di-tert-amyl disulfide34965-30-5
di-2-thienyl disulfide6911-51-9
2-ethoxythiazole15679-19-3
ethyl 2-hydroxyethyl sulfide110-77-0
2-ethyl-4-methylthiazole15679-12-6
ethyl 1-propenyl sulfide36784-55-1
5-ethyl-4-methylthiazole31883-01-9
4-ethyl-5-methylthiazole52414-91-2
2-ethylthiazole15679-09-1
2-ethylthiophene872-55-9
2,4-dithiapentane1618-26-4
furfuryl isopropyl sulfide1883-78-9
furfuryl methyl sulfide1438-91-1
2-hexylthiophene18794-77-9
2-isobutyl-4,5-dimethylthiazole53498-32-1
2-isobutyl-4-methylthiazole61323-24-8
2-isobutyl-5-methylthiazole72611-71-3
2-isobutylthiazole18640-74-9
2-isopropyl-4-methylthiazole15679-13-7
lenthionine292-46-6
methional3268-49-3
methional diethyl acetal16630-61-8
methional glyceryl acetal 
methional propyleneglycol acetal59007-89-5
methionol505-10-2
methyl 1-propenyl sulfide10152-77-9
methyl 2-methyl-3-furyl disulfide65505-17-1
methyl 5-methyl-2-furyl sulfide13678-59-6
methyl 5-methylfurfuryl disulfide78818-78-7
butyl methyl sulfide628-29-5
dimethyl disulfide624-92-0
ethyl methyl disulfide20333-39-5
ethyl methyl sulfide624-89-5
furfuryl methyl disulfide57500-00-2
methyl octyl sulfide3698-95-1
methyl 2-methylphenyl disulfide35379-09-0
methyl phenyl disulfide14173-25-2
methyl propyl disulfide2179-60-4
methyl propyl sulfide3877-15-4
methyl propyl trisulfide17619-36-2
2-methyl-2-thiazoline2346-00-1
2-(furfurylthio)-(3or5or6)-methylpyrazine65530-53-2
59303-07-0
2-methyl-(3or5or6)-(methylthio)pyrazine2882-20-4
2884-13-1
2884-14-2
67952-65-2
68378-12-1
2-methyl-3-furyl 2-methyl-3-tetrahydrofuryl disulfide252736-40-6
methyl 2-methyl-3-furyl sulfide63012-97-5
2-methyl-4-propyl-1,3-oxathiane67715-80-4
2-methyl-5,7-dihydrothieno[3,4-d]pyrimidine36267-71-7
5-ethenyl-4-methylthiazole1759-28-0
2-methylthiazole3581-87-1
4-methylthiazole693-95-8
5-methylthiazole3581-89-3
2-methylthiazolidine24050-16-6
2-ethyl-3-(methylthio)pyrazine72987-62-3
3-(methylthio)butanal16630-52-7
4-(methylthio)butanol20582-85-8
2-(methylthio)ethanol5271-38-5
2-methylthiophene554-14-3
3-methylthiophene616-44-4
3-(methylthio)propylamine4104-45-4
(methylthio)pyrazine21948-70-9
2-pentylthiophene4861-58-9
diphenyl disulfide882-33-7
1-propenyl propyl disulfide5905-46-4
1-propenyl propyl sulfide33922-70-2
dipropyl disulfide629-19-6
2-propylthiazole17626-75-4
2-propylthiazolidine24050-10-0
spiro[2,4-dithia-1-methyl-8-oxa-bicyclo[3.3.0]octane-3,3'-(1'-oxa-2'-methyl)cyclopentane] and spiro[dithia-6-methyl-7-oxa-bicyclo[3.3.0]octane-3,3'-(1'-oxa-2'-methyl)cyclopentane]38325-25-6
38325-26-7
thiolane110-01-0
thiazole288-47-1
thiazolidine-2,4-dione2295-31-0
methyl phenyl sulfide100-68-5
thiophene110-02-1
2,4,6-trimethyl-5,6-dihydro-1,3,5-dithiazine638-17-5
2,8-epithio-p-menthane68398-18-5
2,4,5-trimethylthiazole13623-11-5
2,2,4,4,6,6-hexamethyl-1,3,5-trithiane828-26-2
2,3,5-trithiahexane42474-44-2
1,2,4-trithiolane289-16-7
2-sec-butyl-4,5-dimethyl-3-thiazoline65894-82-8
2-(furfurylthio)-3-methylpyrazine59303-07-0
2-(methylthio)benzothiazole615-22-5
2,4,6-triethyl-5,6-dihydro-4H-1,3,5-dithiazine54717-17-8
2-isopropyl-3-(methylthio)pyrazine67952-59-4
2-methyl-1,3-dithiolane5616-51-3
2-(methylthio)acetaldehyde23328-62-3
2-methylthiolane1795-09-1
2-(methylthio)thiazole5053-24-7
4-methyl-2-pentylthiazole96693-92-4
2-pentylthiazole37645-62-8
4-methyl-2-propylthiazole52414-87-6
2,4,6-trimethyl-3,4,5,6-tetrahydro-2H-1,3,5-thiadiazine 
3,5-diethyl-1,2,4-trithiolane54644-28-9
3-methyl-1,2,4-trithiane43040-01-3
3-thienylcarboxylic acid88-13-1
2-ethyl-4,5-dimethyl-3-thiazoline76788-46-0
benzothiophene95-15-8
bis(2-methylbutyl) disulfide 
diallyl trisulfide2050-87-5
dibutyl disulfide629-45-8
2-methyldihydrothiazole 
diisobutyl disulfide1518-72-5
dipentyl disulfide112-51-6
di-sec-butyl disulfide5943-30-6
isobutyl methyl disulfide67421-83-4
mintsulfide72445-42-2
2,4,6-trithiaheptane6540-86-9
bis(2,5-dimethyl-3-furyl) disulfide28588-73-0
2,4,6-triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine74595-94-1
2-methyl-3-furyl propyl disulfide61197-09-9
4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one121746-18-7
6-methyl-2,3-dihydrothieno[2,3-c]furan26693-24-3
2,5-dihydroxy-1,4-dithiane40018-26-6
3,5-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
(2or4)-ethyl-(4or2),6-dimethyldihydro-1,3,5-dithiazine54717-13-4
54717-14-5
4-methyl-2-propyl-1,3-oxathiane1064678-08-5
2-ethyl-4-methyl-3-thiazoline41803-21-8
diisoamyl trisulfide955371-64-9
3,5-diisobutyl-1,2,4-trithiolane92900-67-9
methyl 1-propenyl disulfide5905-47-5
diethyl trisulfide3600-24-6
2,5-dithiahexane6628-18-8
furfuryl 2-methyl-3-furyl disulfide109537-55-5
[To List of designated additives]

Thiols (Thioalcohols) (except those generally recognized as highly toxic)
The examples of flavorings used for food in Japan: The result of investigation by Japan Flavor & Fragrance Material Association in 2013.
Compound
CAS No.
2-propenethiol870-23-5
benzenethiol108-98-5
benzenemethanethiol100-53-8
2,3-butanedithiol4532-64-3
butanethiol109-79-5
2-butanethiol513-53-1
cyclohexanethiol1569-69-3
cyclopentanethiol1679-07-8
1,2-ethanedithiol540-63-6
2,3-dimercaptopropanol59-52-9
2,5-dimethyl-3-furanthiol55764-23-3
3,3-dimethylbutanethiol1638-98-8
dodecanethiol112-55-0
ethanethiol75-08-1
2-(ethylthio)phenol29549-60-8
2-furanmethanethiol98-02-2
heptanethiol1639-09-4
hexadecanethiol2917-26-2
1,6-hexanedithiol1191-43-1
3-methylbutanethiol541-31-1
2-propanethiol75-33-2
3-[(2-mercapto-1-methylpropyl)thio]-2-butanol54957-02-7
3-hydroxy-2-butanethiol37887-04-0
54812-86-1
2-methoxybenzenethiol7217-59-6
2-hydroxyethanethiol60-24-2
3-mercaptohexanol51755-83-0
pyrazinylmethanethiol59021-02-2
(2or3or10)-mercaptopinane6588-78-9
23832-18-0
72361-41-2
4-methoxy-2-methyl-2-butanethiol94087-83-9
methanethiol74-93-1
2-methyl-3-furanthiol28588-74-1
2-methyl-3-tetrahydrofuranthiol57124-87-5
2-methyl-4,5-dihydro-3-furanthiol26486-13-5
(4-methylphenyl)methanethiol4498-99-1
3-methyl-2-butanethiol2084-18-6
2-methylbutanethiol1878-18-8
2-methyl-2-propanethiol75-66-1
2-naphthalenethiol91-60-1
1,9-nonanedithiol3489-28-9
1,8-octanedithiol1191-62-4
octanethiol111-88-6
2,4,4,6,6-pentamethyl-2-heptanethiol 
2-pentanethiol2084-19-7
pentanethiol110-66-7
2-phenylethanethiol4410-99-5
1-p-menthene-8-thiol71159-90-5
1,2-propanedithiol814-67-5
propanethiol107-03-9
2-pyrazinylethanethiol35250-53-4
2-pyridinylmethanethiol2044-73-7
thioterpineol68921-82-4
71159-90-5
2-thienylmethanethiol6258-63-5
2-thiophenethiol7774-74-5
1-(2-thienyl)ethanethiol94089-02-8
thiogeraniol39067-80-6
thiolinalool39707-47-6
2-methylbenzenethiol137-06-4
1,4-butanedithiol1191-08-8
2-mercaptobenzothiazole149-30-4
3-{[2-methyl-(2or4),5-dihydro-3-furyl]thio}-2-methyltetrahydrofuran-3-thiol38325-24-5
2-thiazoline-2-thiol96-53-7
134469-06-0
3-mercapto-2-methylbutanol227456-33-9
3-mercapto-2-methylpentanol227456-27-1
3-mercapto-3-methylbutanol34300-94-2
4-ethoxy-2-methyl-2-butanethiol 
ethanedithiol26914-40-9
hexanethiol111-31-9
2-methylpropanethiol513-44-0
mercaptoacetaldehyde diethyl acetal 
3-methyl-2-butenethiol5287-45-6
1,1-dimethylheptanethiol25360-10-5
2,6-dimethylbenzenethiol118-72-9
(S)-1-methoxy-3-heptanethiol400052-49-5
1,3-propanedithiol109-80-8
1-phenylethanethiol6263-65-6
5-methyl-2-furanmethanethiol59303-05-8
methanedithiol6725-64-0
4-mercapto-4-methyl-2-pentanol31539-84-1
bis(1-mercaptopropyl)sulfide53897-60-2
1,1-propanedithiol88497-17-0
3-pentanethiol616-31-9
3-hydroxy-2-methylbutanethiol33959-27-2
2-heptanethiol628-00-2
[To List of designated additives]